Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02612-18. doi: 10.1128/AAC.02612-18. Print 2019 May.

Abstract

Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.

Keywords: Klebsiella pneumoniae; gentamicin; microarray; transdermal delivery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Disease Models, Animal
  • Gentamicins / therapeutic use*
  • Klebsiella Infections / drug therapy*
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / pathogenicity*
  • Mice

Substances

  • Anti-Bacterial Agents
  • Gentamicins