Chemical ribosylation of 5-substituted 1,2,4-triazole-3-carboxylates

Alexander N Prutkov; Mikhail V Chudinov; Andrey V Matveev; Lyubov E Grebenkina; Yulia V Berezovskaya

doi:10.1080/15257770.2019.1576881

Chemical ribosylation of 5-substituted 1,2,4-triazole-3-carboxylates

Nucleosides Nucleotides Nucleic Acids. 2019;38(8):550-566. doi: 10.1080/15257770.2019.1576881. Epub 2019 Mar 11.

Authors

Alexander N Prutkov¹, Mikhail V Chudinov², Andrey V Matveev², Lyubov E Grebenkina¹, Yulia V Berezovskaya³

Affiliations

¹ a Moscow Politechnical University , Moscow , Russia.
² b Lomonosov Institute of Fine Chemical Technologies , Moscow Technological University , Moscow , Russia.
³ c Moscow Institute of Physics and Technology (State University) , Dolgoprudny , Russia.

PMID: 30856058
DOI: 10.1080/15257770.2019.1576881

Abstract

The chemical ribosylation pathways of 5-substituted-1,2,4-triazole-3-carboxylates are discussed. For the products of the chemical synthesis of the 3(5)-alkyl- or 3(5)-aryl-substituted ribavirin analogues the anomer configuration and isomer composition were determined.

Keywords: Ribavirin analogues; nucleoside synthesis; ribosylation.

MeSH terms

Carboxylic Acids / chemical synthesis*
Catalysis
Isomerism
Molecular Structure
Ribavirin / analogs & derivatives*
Ribavirin / chemical synthesis*
Structure-Activity Relationship
Triazoles / chemical synthesis*

Substances

Carboxylic Acids
Triazoles
Ribavirin