KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients

Xin-Hui Fu; Zhi-Ting Chen; Wen-Hui Wang; Xin-Juan Fan; Yan Huang; Xiao-Bin Wu; Jing-Lin Huang; Jing-Xuan Wang; Han-Jie Lin; Xiao-Li Tan; Lei Wang; Jian-Ping Wang

doi:10.7150/jca.27899

KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients

J Cancer. 2019 Jan 29;10(4):821-828. doi: 10.7150/jca.27899. eCollection 2019.

Authors

Xin-Hui Fu^{1

2

3}, Zhi-Ting Chen^{1

2

3}, Wen-Hui Wang⁴, Xin-Juan Fan³, Yan Huang³, Xiao-Bin Wu⁵, Jing-Lin Huang^{1

2

3}, Jing-Xuan Wang^{1

2

3}, Han-Jie Lin^{1

2

3}, Xiao-Li Tan^{1

2

3}, Lei Wang⁵, Jian-Ping Wang^{1

2}

Affiliations

¹ Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
² Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
³ Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
⁴ Department of Information and Technology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
⁵ Department of GI Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Abstract

This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of KRAS, BRAF and PIK3CA mutations were 4.1%, 1.2% and 3.5%, respectively. BRAF mutations were significantly concentrated in stage III and IV gastric cancer (P=0.009). KRAS G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (P=0.013). In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival.

Keywords: BRAF; Gastric cancer; KRAS; Mutation; PIK3CA.