Non-canonical processes that shape the cell migration landscape

Ritankar Majumdar; Kaylee Steen; Pierre A Coulombe; Carole A Parent

doi:10.1016/j.ceb.2018.12.013

Non-canonical processes that shape the cell migration landscape

Curr Opin Cell Biol. 2019 Apr:57:123-134. doi: 10.1016/j.ceb.2018.12.013. Epub 2019 Mar 7.

Authors

Ritankar Majumdar¹, Kaylee Steen², Pierre A Coulombe³, Carole A Parent⁴

Affiliations

¹ Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
² Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
³ Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
⁴ Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: parentc@umich.edu.

Abstract

Migration is a vital, intricate, and multi-faceted process that involves the entire cell, entails the integration of multiple external cues and, at times, necessitates high-level coordination among fields of cells that can be physically attached or not, depending on the physiological setting. Recent advances have highlighted the essential role of cellular components that have not been traditionally considered when studying cell migration. This review details how much we recently learned by studying the role of intermediate filaments, the nucleus, extracellular vesicles, and mitochondria during cell migration.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Movement*
Humans
Intermediate Filaments / physiology
Mitochondria / physiology
Organelles / metabolism

Abstract

Publication types

MeSH terms

Grants and funding