Stem Cell Aging? Blame It on the Niche

Christopher S Morrow; Darcie L Moore

doi:10.1016/j.stem.2019.02.011

Stem Cell Aging? Blame It on the Niche

Cell Stem Cell. 2019 Mar 7;24(3):353-354. doi: 10.1016/j.stem.2019.02.011.

Authors

Christopher S Morrow¹, Darcie L Moore²

Affiliations

¹ Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
² Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: darcie.moore@wisc.edu.

PMID: 30849364
DOI: 10.1016/j.stem.2019.02.011

Abstract

The molecular basis for the neural stem cell quiescence-to-activation transition has become an important focus in the study of adult neurogenesis. Recently in Cell, Kalamakis et al. (2019) show that aged neural stem cells face greater barriers to exiting quiescence, imposed by the niche through inflammation and altered Wnt signaling.

Publication types

Comment

MeSH terms

Adult
Brain
Cellular Senescence
Humans
Neural Stem Cells*
Neurogenesis
Stem Cell Niche*

Abstract

Publication types

MeSH terms

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