Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases

Meenu Mehta; Deeksha; Neha Sharma; Manish Vyas; Navneet Khurana; Pawan Kumar Maurya; Harjeet Singh; Terezinha Pinto Andreoli de Jesus; Harish Dureja; Dinesh Kumar Chellappan; Gaurav Gupta; Ridhima Wadhwa; Trudi Collet; Philip M Hansbro; Kamal Dua; Saurabh Satija

doi:10.1016/j.cbi.2019.02.021

Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases

Chem Biol Interact. 2019 May 1:304:10-19. doi: 10.1016/j.cbi.2019.02.021. Epub 2019 Mar 5.

Authors

Meenu Mehta¹, Deeksha¹, Neha Sharma¹, Manish Vyas¹, Navneet Khurana¹, Pawan Kumar Maurya², Harjeet Singh³, Terezinha Pinto Andreoli de Jesus⁴, Harish Dureja⁵, Dinesh Kumar Chellappan⁶, Gaurav Gupta⁷, Ridhima Wadhwa⁸, Trudi Collet⁹, Philip M Hansbro¹⁰, Kamal Dua¹¹, Saurabh Satija¹²

Affiliations

¹ School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara, 144411, Punjab, India.
² Department of Biochemistry, Central University of Haryana, Jant-Pali, Mahendergarh District-123031, Haryana, India.
³ National Medicinal Plants Board, Ministry of AYUSH, New Delhi, India.
⁴ Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
⁵ Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana 124001, India.
⁶ Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
⁷ School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India.
⁸ Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
⁹ Innovative Medicines Group, Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane 4059, Queensland, Australia.
¹⁰ Centre for Inflammation, Centenary Institute, Sydney, NSW 2050 , Australia; School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
¹¹ Centre for Inflammation, Centenary Institute, Sydney, NSW 2050 , Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: Kamal.Dua@uts.edu.au.
¹² School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara, 144411, Punjab, India. Electronic address: saurabh.21958@lpu.co.in.

PMID: 30849336
DOI: 10.1016/j.cbi.2019.02.021

Abstract

Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.

Keywords: Antimicrobial peptides; Asthma; Inflammation; Macrophages; Nanoparticles; Novel drug delivery systems; Respiratory diseases.

Publication types

Review

MeSH terms

Drug Delivery Systems*
Humans
Inflammation / drug therapy
Macrophages / drug effects*
Respiratory Tract Diseases / drug therapy*