Blood Glucose Regulation for Post-Operative Patients with Diabetics and Hypertension Continuum: A Cascade Control-Based Approach

J Med Syst. 2019 Mar 7;43(4):95. doi: 10.1007/s10916-019-1224-6.

Abstract

Management of glycemic level in post-operative condition is critical for hypertensive patients and the post-operative stress may results in hyperglycemia, hyper insulin and osmotic diuresis. Recent medical research shows that diabetic and hypertension hands together in a significant overlap in its etiology and its disease mechanism. It is clear that there is a call for monitoring in the parameter and controlling the glucose level particularly in the presence of hypertension. This paper proposes the novel complex (cascade) control system to control the insulin infusion level particularly in the presence of hypertension. Based on the requirements the structure has been designed and the simulation results indicates that the proposed control strategy shows better results and may achieve potentially better glycemic control to the hypersensitive diabetic patients.

Keywords: Cascade control; Hypertension; Mathematical model; Optimal insulin infusion.

MeSH terms

  • Algorithms
  • Antihypertensive Agents / therapeutic use
  • Blood Glucose
  • Blood Pressure
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / physiopathology
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology*
  • Hypertension / physiopathology
  • Hypoglycemic Agents / administration & dosage*
  • Hypoglycemic Agents / therapeutic use
  • Insulin / administration & dosage*
  • Insulin / therapeutic use
  • Models, Biological
  • Nitroprusside / therapeutic use
  • Postoperative Care / methods*

Substances

  • Antihypertensive Agents
  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Nitroprusside