Preliminary results of high fibular osteotomy (HFO) and cartilage regeneration procedure for medial compartment osteoarthritis of knee with varus deformity

Hussain S H Jaheer; Asode Ananthram Shetty; Nam Yong Choi; Ki-Won Kim; Selvan V Thirumal; Jun Seob Song; Ki Seong Kim; You Seung Chun; Seok Jung Kim

doi:10.1016/j.reth.2019.02.001

Preliminary results of high fibular osteotomy (HFO) and cartilage regeneration procedure for medial compartment osteoarthritis of knee with varus deformity

Regen Ther. 2019 Feb 22:10:112-117. doi: 10.1016/j.reth.2019.02.001. eCollection 2019 Jun.

Authors

Hussain S H Jaheer¹, Asode Ananthram Shetty², Nam Yong Choi³, Ki-Won Kim³, Selvan V Thirumal¹, Jun Seob Song⁴, Ki Seong Kim⁵, You Seung Chun³, Seok Jung Kim³

Affiliations

¹ Department of Orthopaedic Surgery, Trauma & Orthopaedic Speciality Hospital (TOSH), Chennai, India.
² Canterbury Christ Church University, Faculty of Health and Social Sciences, 30 Pembroke Court, Chatham Maritime, Kent, ME4 4UF, United Kingdom.
³ Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
⁴ Department of Orthopaedic Surgery, JS Hospital, Seoul, South Korea.
⁵ Department of Orthopaedic Surgery, Janghowon St. Mary's Hospital, Gyeonggi-do, South Korea.

Abstract

Purpose: High fibular osteotomy (HFO) is a simple surgical technique to reduce pain and improve function in patients with osteoarthritis via fibular osteotomy. We report short-term results of HFO and mesenchymal cell induced chondrogenesis (MCIC) for the treatment of osteoarthritis of knee with varus deformity.

Patients and methods: 45 symptomatic patients with 14 males and 31 females age ranging from 40 to 75 years were treated by HFO and MCIC. Main lesions involved medial compartment of knee and lateral compartment with normal to mild lesions of lateral meniscus and articular cartilage, amenable to treatment via partial meniscectomy or observation.

Results: Knee injury and Osteoarthritis Outcome score and Lysholm showed a statistically significant increase and VAS, varus angle in X-ray showed a statistically significant decrease. A statistically significant difference between preoperative and postoperative scores was detected in male and female patients without any sexual differences.

Conclusion: High fibular osteotomy and mesenchymal cell induced chondrogenesis can be considered as a good treatment option for medial compartment osteoarthritis of knee with varus deformity.

Keywords: BMAC, bone marrow aspirate concentrate; HA, hyaluronic acid; HFO, High fibular osteotomy; HTO, high tibial osteotomy; High fibular osteotomy; KOOS, Knee injury and Osteoarthritis Outcome score; Knee; MCIC, mesenchymal cell induced chondrogenesis; Mesenchymal cell induced chondrogenesis (MCIC); Osteoarthritis; VAS, visual analogue score; Varus deformity.