Mechanism of Action of a New Anti-CD38 Antibody: Enhancing Myeloma Immunotherapy

Clin Cancer Res. 2019 May 15;25(10):2946-2948. doi: 10.1158/1078-0432.CCR-19-0260. Epub 2019 Mar 7.

Abstract

Antibody therapy is a treatment option for several diseases, including multiple myeloma. The logic behind it is relatively simple: A target molecule is selected because of its expression on tumor cells, and the antibody delivers cytotoxic effects. Therapeutic results in multiple myeloma indicate that the anti-CD38 antibodies may have relevant immunotherapeutic properties.See related article by Moreno et al., p. 3176.

Publication types

  • Comment

MeSH terms

  • ADP-ribosyl Cyclase 1 / immunology
  • Antibodies, Monoclonal
  • Humans
  • Immunologic Factors
  • Immunotherapy
  • Multiple Myeloma*

Substances

  • Antibodies, Monoclonal
  • Immunologic Factors
  • ADP-ribosyl Cyclase 1