Rationale and objectives: To demonstrate the improved enhancement degree and uniformity in coronary CT angiography (CCTA) on a 16 cm wide-coverage CT with a new bolus tracking method enabled by free-breathing, in comparison with the conventional breath-holding method.
Materials and methods: A total of 200 patients with suspected coronary heart disease were randomly divided into two groups for CCTA: Group A (n = 100, free-breathing) started CCTA with 2.2 seconds delay after the attenuation in aorta reached 250 HU; Group B (n = 100, breath-holding), used the standard protocol of 80 HU threshold and 8.4 seconds delay. Both groups used the contrast dose rate of 25 mgI/kg/s. CT value and standard deviation in aortic sinus (AS), right coronary artery, left anterior descending, left circumflex, and pericardial fat were measured. Contrast-to-noise ratio for vessels was calculated. Two experienced Radiologists independently reviewed image quality using a 5-point scale (1: nondiagnostic-5: excellent).
Results: There was no difference in contrast dose, radiation dose, heart rate, and qualitative image quality between the two groups (all p > 0.05). However, Group A had higher mean enhancement in vessels (404 ± 66 HU) than Group B (321 ± 69 HU), and lower coefficients of variation of CT value in aortic sinus, right coronary artery, left anterior descending, and left circumflex (16.3%, 17.7%, 19.2%, and 20.5% vs 21.5%, 22.3%, 23.6%, and 22.9%, respectively), (all p < 0.05).
Conclusion: A new bolus tracking method enabled by free-breathing in CCTA on a 16 cm wide-coverage CT system increases the enhancement degree and uniformity in coronary arteries, compared with the conventional breath-holding method.
Keywords: Breath-holding; Coronary CT angiography; Free-breathing; Uniformity.
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