Ketamine: A Paradigm Shift for Depression Research and Treatment

John H Krystal; Chadi G Abdallah; Gerard Sanacora; Dennis S Charney; Ronald S Duman

doi:10.1016/j.neuron.2019.02.005

Ketamine: A Paradigm Shift for Depression Research and Treatment

Neuron. 2019 Mar 6;101(5):774-778. doi: 10.1016/j.neuron.2019.02.005.

Authors

John H Krystal¹, Chadi G Abdallah², Gerard Sanacora³, Dennis S Charney⁴, Ronald S Duman⁵

Affiliations

¹ Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA; Yale-New Haven Hospital, New Haven, CT, USA. Electronic address: john.krystal@yale.edu.
² Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.
³ Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; Yale-New Haven Hospital, New Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA.
⁴ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁵ Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA.

Abstract

Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Antidepressive Agents / adverse effects
Antidepressive Agents / pharmacology
Antidepressive Agents / therapeutic use*
Excitatory Amino Acid Antagonists / adverse effects
Excitatory Amino Acid Antagonists / pharmacology
Excitatory Amino Acid Antagonists / therapeutic use*
Humans
Ketamine / adverse effects
Ketamine / pharmacology
Ketamine / therapeutic use*
Synaptic Transmission / drug effects

Substances

Antidepressive Agents
Excitatory Amino Acid Antagonists
Ketamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding