Renal effects of general anesthesia from old to recent studies

J Cell Physiol. 2019 Aug;234(10):16944-16952. doi: 10.1002/jcp.28407. Epub 2019 Mar 6.

Abstract

Various types of anesthesia are being utilized to maintain physiologically secured surgical conditions. Nearly all categories of general anesthesia are characterized by various perioperative and postoperative complications. These shortcomings are important aspects that need to be considered by the anesthesiologist and surgeon before administration of these compounds. The renal effects of anesthesia play an important role in understanding possible systemic changes due to the fact that the kidney has a direct or indirect impact on nearly all the systems of the body. Various studies have been conducted to find out changes in renal parameters and its systemic effects upon administration of the anesthesia and its postoperative repercussions. Besides that, the impaired renal function might have an impact on the excretion of anesthetic metabolites, which can lead to long-term dysfunction. Patients with a previous history of disease ought to be brought under consideration because these chemicals can ameliorate pre-existent symptoms. This review is intended to discuss the early and latest studies based on the effects of general anesthesia on the renal system.

Keywords: general anesthesia; renal dysfunction; renal effects; renal impairment.

Publication types

  • Review

MeSH terms

  • Anesthesia, General / adverse effects*
  • Anesthesia, General / methods
  • Anesthetics, General / adverse effects*
  • Animals
  • Humans
  • Kidney / drug effects*

Substances

  • Anesthetics, General