Aim: We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma.
Patients and methods: Patients with lymph node metastasis from oral cancer were treated with IACRT using cisplatin plus docetaxel combined with hyperthermia prior to surgical removal 8 weeks after completion of IACRT and hyperthermia. The locoregional control and overall survival rates were calculated using the Kaplan-Meier method.
Results: A total of 35 patients received the combination therapy of whom 26 received it as definitive treatment and in the rest, it was administered as preoperative treatment. The 5-year locoregional control and overall survivaI rates were 95.6% and 80.2% in the definitive-treatment group, and 100% and 66.6% in the preoperative-treatment group, respectively.
Conclusion: The combination therapy provided good outcomes in patients with lymph node metastases from advanced oral cancer.
Keywords: Oral squamous cell carcinoma; cervical lymph node metastasis; concurrent radiotherapy; hyperthermia; retrograde superselective intra-arterial chemotherapy.
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.