Objective: To summarize the clinical manifestation, treatment and prognosis of anterior ischemic optic neuropathy(AION) which was the manifestation of optic neuropathy related with Behcet's disease (BD). Methods: Retrospective series of case studies. The clinical data of 6 cases (9 eyes) of AION associated with BD who were hospitalized at the neurology ward of Beijing Tongren Hospital from February to June in 2016 were collected, the clinical characteristics of these patients were summarized, visual acuity were compared by using Wingerchuk visual grade before and after treatment. Results: Among the 6 patients with AION associated with BD, there were 4 males and 2 female, aged 38-60 years. All patients were acute onset, 3 cases had the onset of one eye, 2 cases with the onset of both eyes and 1 case with successively onset of both eyes. Optic nerve was damaged in 6 cases (9 eyes), only 1 case felt pain of eyes, the best corrected visual acuity of 4 eyes were less than 0.1, optic disk edema and linear bleeding around optic disk were oberved in all patients, the lower half visual field defect was the most common damage type (5 eyes), P100 latency of visual evoked potential prolonged in all patients, optic nerve MRI showed abnormal signal of optic nerve involvement in 2 patients. All patients were treated with corticosteroids and followed for 3 months, there was significant improvement in 1 eye of which the vision improved above 3 grade, and improvement in 6 eyes of which vision improved for 1-2 grade, while there has been no change in 2 eyes. Conclusions: BD may be the etiology of AION. Visual impairment of this kind of patients is relatively serious, visual function is expected to improve with early treatment. (Chin J Ophthalmol, 2019, 55:203-207).
目的： 总结以前部缺血性视神经病变（AION）为表现的白塞病相关视神经病的临床表现及治疗转归。 方法： 回顾性系列病例研究。选取2016年2至6月在首都医科大学附属北京同仁医院神经内科住院的6例（9只眼）表现为AION的白塞病患者临床资料，总结患者的临床特点，并对治疗前、后的视力采用Wingerchuk视力分级进行分析。 结果： 6例白塞病相关AION患者中男性4例，女性2例；年龄38~60岁；均急性起病。3例单眼发病、2例双眼同时发病、1例双眼先后发病。视神经损伤6例（9只眼），伴眼痛者1例；视力损伤最严重时最佳矫正视力≤0.1者4只眼，9只眼均有视盘水肿和盘周线状出血，视野损伤多表现为水平下半视野缺损（5只眼）。视觉诱发电位均提示P100潜伏期延长；2例患者视神经MRI提示受累眼视神经信号异常；所有患者经糖皮质激素治疗3个月后随访视力变化，1只眼明显改善（视力提高3级及以上），6只眼好转（视力提高1~2级），2只眼无变化。 结论： 白塞病可能是AION的病因，这类患者视功能损伤多比较严重，早期治疗后视功能有望改善。（中华眼科杂志，2019，55：203-207）.
Keywords: Behcet syndrome; Optic neuropathy, ischemic; Papilledema.