Anaphylactic Reaction to Tc-99m Macrosalb

Nanno Schreuder; Quincy de Hoog; Wouter van der Bruggen; Eugène P van Puijenbroek

doi:10.1007/s40800-019-0097-4

Anaphylactic Reaction to Tc-99m Macrosalb

Drug Saf Case Rep. 2019 Mar 5;6(1):4. doi: 10.1007/s40800-019-0097-4.

Authors

Nanno Schreuder^{1

2}, Quincy de Hoog³, Wouter van der Bruggen⁴, Eugène P van Puijenbroek^{3

5}

Affiliations

¹ Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology and Economics, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands. n.schreuder@rug.nl.
² GE Healthcare Radiopharmacy Zwolle, Dokter Spanjaardweg 1A, Zwolle, The Netherlands. n.schreuder@rug.nl.
³ Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology and Economics, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands.
⁴ Department of Nuclear Medicine, Slingeland Ziekenhuis, Kruisbergseweg 25, Doetinchem, The Netherlands.
⁵ Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 's Hertogenbosch, The Netherlands.

Abstract

A 49-year-old woman developed an anaphylactic reaction to Tc-99m macrosalb used for pulmonary scintigraphy. The patient received an intravenous injection of Tc-99m macrosalb 120 MBq, containing macroaggregates of human albumin 0.14 mg. Within 1 min she developed itching all over her body, an itching throat and dyspnoea. This was followed by urticaria and facial oedema. She was diagnosed with an anaphylactic shock. The patient received clemastine and prednisone, and fully recovered after release from the hospital. According to the Naranjo assessment algorithm, the relationship between the allergic reaction and the administration of Tc-99m macrosalb should be considered as 'probable'.