Norlichexanthone produced by cultured endolichenic fungus induced from Pertusaria laeviganda and its antioxidant activity

Hiroko Kawakami; Chihiro Suzuki; Haruka Yamaguchi; Kojiro Hara; Masashi Komine; Yoshikazu Yamamoto

doi:10.1080/09168451.2019.1585746

Norlichexanthone produced by cultured endolichenic fungus induced from Pertusaria laeviganda and its antioxidant activity

Biosci Biotechnol Biochem. 2019 Jun;83(6):996-999. doi: 10.1080/09168451.2019.1585746. Epub 2019 Mar 5.

Authors

Hiroko Kawakami¹, Chihiro Suzuki¹, Haruka Yamaguchi¹, Kojiro Hara¹, Masashi Komine¹, Yoshikazu Yamamoto¹

Affiliation

¹ a Department of Biological Production , Akita Prefectural University , Akita , Japan.

PMID: 30835638
DOI: 10.1080/09168451.2019.1585746

Abstract

Endolichenic fungi, nonobligate microfungi that live in lichen, are promising as new bioresources of pharmacological compounds. We found that norlichexanthone isolated from the endolichenic fungus in Pertusaria laeviganda exhibited high antioxidant activity. Norlichexanthone produced by endolichenic fungus had the antioxidant activity with same level of ascorbic acid. This is the first report of high antioxidant activity of norlichexanthone. Abbreviations: AAPH: 2,2'-azobis (2-methylpropionamidine) dihydrochloride; DPPH: 2,2-diphenyl-1-picrylhydrazyl; FL: fluorescein sodium salt; HPLC-PDA: high-performance liquid chromatography with photodiode array; LC-ESI-MS: liquid chromatography with electrospray ionization mass spectrometry; ORAC: oxygen radical absorbance capacity; PB: phosphate buffer; ROS: reactive oxygen species; TLC: thin-layer chromatography.

Keywords: Endolichenic fungi; antioxidant activity; norlichexanthone.

MeSH terms

Antioxidants / pharmacology*
Ascomycota / metabolism*
Chromatography, High Pressure Liquid / methods
Chromatography, Thin Layer / methods
Lichens / microbiology*
Spectrum Analysis / methods
Xanthones / isolation & purification
Xanthones / metabolism*
Xanthones / pharmacology*

Substances

Antioxidants
Xanthones
norlichexanthone