Abstract
A new (1, grincamycin L) and two known (2 and 3) angucycline derivatives were obtained from the fermentation of deepsea-derived Streptomyces lusitanus OUCT16-27 strain. The structures of 1-3 were elucidated based on the LC-MS analysis together with 1D and 2D NMR data assignment. In the antibacterial assay, 1 and 2 exhibited moderate growth inhibitions against multi-drug resistant (MDR) strains of E. faecium, E. faecalis and S. aureus with the minimum inhibitory concentrations (MICs) of 3.12-6.25 µg/mL.
Keywords:
Deepsea-derived Streptomyces; angucycline; antibiotics; multi-drug resistance.
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Drug Evaluation, Preclinical
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Drug Resistance, Multiple, Bacterial / drug effects
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Enterococcus faecalis / drug effects
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Enterococcus faecium / drug effects
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Escherichia coli / drug effects
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Fermentation
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Indian Ocean
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
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Streptomyces / genetics
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Streptomyces / isolation & purification
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Streptomyces / metabolism
Substances
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Anthraquinones
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Anti-Bacterial Agents
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grincamycin