[PROGNOSTICATING LONG-TERM CORONOGENIC COMPLICATIONS IN PATIENTS AFTER ARTERIAL SWITCH OPERATION]

Georgian Med News. 2019 Jan:(286):7-13.
[Article in Russian]

Abstract

The goal of the research was to elaborate a model for prognosticating the probability of the development of long-term coronogenic complications after the arterial switch operation. A single-center retrospective cohort study of the outcomes of treating 248 patients with TGA has been conducted. All the patients underwent an AS operation at the clinic of Bakulev National Medical Research Center of Cardiovascular Surgery. The study covered patients who had had TGA with intact ventricular septum, TGA with ventricular septal defect (TGA-VSD), obstruction of the right or left ventricle outflow tract (RVOT, LVOT), aortic arch hypoplasia and aorta coarctation. The mean age at the moment of the AS operation was 29.9 (+/-3.5) days. The patients with TGA and intact VS who had been admitted at an age of more than 14 days underwent the pulmonary artery narrowing operation at the 1st stage and the AS operation at the 2nd stage. Among the patients who underwent the operation in 1 stage, the mean age was 13.4 (+/-2.4) days. The mean age was 6.9 (+/-1.47) months at the moment of the radical correction in the group of the children who underwent the 2-staged correction (with narrowing the pulmonary artery). Our study has discovered that 35 patients (14.1%) had long-term coronogenic complications after the AS operation. When diagnosing the complication, the mean age was 48.2 (+/-37.2) months. During the first year of the dynamic observation, the frequency of development of this complication was 20% (7 people) and it amounted to 11.4% (4 people) during the subsequent three years. When further observed, 2 more (5.7%) patients developed CA stenoses. According to the data of the performed study, the stratification of the long-term risk of coronogenic complications after the arterial switch operation is determined by several factors: the patient's aortic coarctation, aortic arch hypoplasia, duration of the AC, cross-clamping the aorta and the VSD diameter.

MeSH terms

  • Arterial Switch Operation*
  • Child
  • Child, Preschool
  • Follow-Up Studies
  • Heart Septal Defects, Ventricular*
  • Heart Ventricles
  • Humans
  • Infant
  • Postoperative Complications
  • Prognosis
  • Retrospective Studies
  • Transposition of Great Vessels*
  • Treatment Outcome