Proteolytic Processing of the Epithelial Adherens Junction Molecule E-Cadherin by Neutrophil Elastase Generates Short Peptides With Novel Wound-Healing Bioactivity

Cell Mol Gastroenterol Hepatol. 2019;7(2):483-486.e8. doi: 10.1016/j.jcmgh.2018.10.012. Epub 2018 Nov 4.

Authors

Marilyn H Gordon¹, Anaïs Chauvin², François-Michel Boisvert², Wallace K MacNaughton³

Affiliations

¹ Department of Physiology and Pharmacology, Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada.
² Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
³ Department of Physiology and Pharmacology, Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada. Electronic address: wmacnaug@ucalgary.ca.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adherens Junctions / metabolism*
Amino Acid Sequence
Antigens, CD / chemistry
Antigens, CD / metabolism
Caco-2 Cells
Cadherins / chemistry
Cadherins / metabolism
Epithelial Cells / metabolism*
Humans
Leukocyte Elastase / metabolism*
Peptides / chemistry
Peptides / pharmacology*
Proteolysis*
Wound Healing / drug effects*

Substances

Antigens, CD
CDH1 protein, human
Cadherins
Peptides
Leukocyte Elastase