Australeols A-F, neuroprotective meroterpenoids from Ganoderma australe

Jiao-Jiao Zhang; Yun Dong; Fu-Ying Qin; Yong-Xian Cheng

doi:10.1016/j.fitote.2019.02.021

Australeols A-F, neuroprotective meroterpenoids from Ganoderma australe

Fitoterapia. 2019 Apr:134:250-255. doi: 10.1016/j.fitote.2019.02.021. Epub 2019 Feb 28.

Authors

Jiao-Jiao Zhang¹, Yun Dong², Fu-Ying Qin¹, Yong-Xian Cheng³

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
² Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China; The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China.
³ Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China. Electronic address: yxcheng@szu.edu.cn.

PMID: 30825574
DOI: 10.1016/j.fitote.2019.02.021

Abstract

Six new meroterpenoids, australeols A-F (1-6), together with nineteen known compounds (7-25), were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13, (-)-19, and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells.

Keywords: Ganoderma australe; Meroterpenoids; Neuroprotection.

MeSH terms

Cell Line
China
Fruiting Bodies, Fungal / chemistry
Ganoderma / chemistry*
Humans
Molecular Structure
Neuroprotective Agents / isolation & purification
Neuroprotective Agents / pharmacology*
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Neuroprotective Agents
Terpenes