Phase-shifting of the transmissibility of macrolide-sensitive and resistant Mycoplasma pneumoniae epidemics in Hong Kong, from 2015 to 2018

Int J Infect Dis. 2019 Apr:81:251-253. doi: 10.1016/j.ijid.2019.02.030. Epub 2019 Feb 26.

Abstract

Mycoplasma pneumoniae is a threat to public health. This pathogen caused an epidemic in Hong Kong during the years 2015-2018. The reproduction number during the initial epidemic was estimated to be 1.7 for macrolide-resistant M. pneumoniae (MRMP) and 1.4 for macrolide-sensitive M. pneumoniae (MSMP). During 2016-2018, the reproduction number remained stable at around 1.0 for both MRMP and MSMP. Phase-shifting and changes in the leading-status between the transmissibilities of MSMP and MRMP were found.

Keywords: Antibiotic resistance; Mycoplasma pneumoniae; Reproduction number; Statistical analysis; Wavelet analysis.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Drug Resistance, Bacterial*
  • Epidemics
  • Female
  • Hong Kong / epidemiology
  • Humans
  • Macrolides / pharmacology*
  • Male
  • Mycoplasma pneumoniae / drug effects*
  • Mycoplasma pneumoniae / genetics
  • Mycoplasma pneumoniae / isolation & purification
  • Mycoplasma pneumoniae / physiology
  • Pneumonia, Mycoplasma / drug therapy
  • Pneumonia, Mycoplasma / epidemiology
  • Pneumonia, Mycoplasma / microbiology*
  • Pneumonia, Mycoplasma / transmission
  • Public Health

Substances

  • Anti-Bacterial Agents
  • Macrolides