PEDOT/FHA nanocomposite coatings on newly developed Ti-Nb-Zr implants: Biocompatibility and surface protection against corrosion and bacterial infections

A Madhan Kumar; Akeem Yusuf Adesina; M A Hussein; Suresh Ramakrishna; N Al-Aqeeli; Sultan Akhtar; S Saravanan

doi:10.1016/j.msec.2019.01.012

PEDOT/FHA nanocomposite coatings on newly developed Ti-Nb-Zr implants: Biocompatibility and surface protection against corrosion and bacterial infections

Mater Sci Eng C Mater Biol Appl. 2019 May:98:482-495. doi: 10.1016/j.msec.2019.01.012. Epub 2019 Jan 4.

Authors

A Madhan Kumar¹, Akeem Yusuf Adesina², M A Hussein², Suresh Ramakrishna³, N Al-Aqeeli⁴, Sultan Akhtar⁵, S Saravanan⁶

Affiliations

¹ Centre of Research Excellence in Corrosion, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. Electronic address: madhankumar@kfupm.edu.sa.
² Centre of Research Excellence in Corrosion, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.
³ Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea; College of Medicine, Hanyang University, Seoul, South Korea.
⁴ Department of Mechanical Engineering, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
⁵ Electron Microscopy Unit, Institute for Research & Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
⁶ Department of life science, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.

PMID: 30813050
DOI: 10.1016/j.msec.2019.01.012

Abstract

The fabrication of bioactive polymer nanocomposite coatings with enhanced biocompatibility and surface protection has been a topic of abundant concern in orthopaedic implant applications. Herein, we electrochemically prepared a novel poly (3,4-ethylenedioxythiophene) (PEDOT) based nanocomposite coatings with different contents of fluoro hydroxyapatite (FHA) nanoparticles on a newly developed Ti-Nb-Zr (TNZ) alloy; an appropriate approach to advance the surface features of TNZ implants. FTIR, XRD, and Raman analyses of the coating confirm the successful preparation of PEDOT/FHA nanocomposite, and XPS validate the chemical interaction between FHA and PEDOT matrix. SEM and TEM examination show the uniform distribution of spherical FHA nanoparticles inside the PEDOT matrix. Hardness and contact angle measurement results showed improving in the hardness and surface wettability of the coated samples respectively. Electrochemical corrosion tests specified that the PEDOT/FHA coatings exhibit higher corrosion protection than the pure PEDOT coatings. The fabricated nanocomposite coating supports the cell adsorption and proliferation of MG-63 cells. Moreover, antibacterial studies against Gram positive and negative bacteria reveal the enhanced antibacterial performance of the coated TNZ substrates. Our results show the potential applications of PEDOT/FHA nanocomposite as a most viable coating for the orthopaedic implants.

Keywords: Antibacterial; Biocompatibility; Corrosion; PEDOT; SBF; Ti implants.

MeSH terms

Alloys / pharmacology*
Anti-Bacterial Agents / pharmacology
Bacterial Infections / pathology*
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Cell Line, Tumor
Coated Materials, Biocompatible / pharmacology*
Corrosion
Dielectric Spectroscopy
Durapatite / chemistry
Durapatite / pharmacology
Electrochemical Techniques
Hardness
Humans
Microbial Sensitivity Tests
Nanocomposites / chemistry*
Nanocomposites / ultrastructure
Niobium / pharmacology*
Photoelectron Spectroscopy
Polymers / pharmacology*
Prostheses and Implants*
Spectrum Analysis, Raman
Wettability
X-Ray Diffraction

Substances

Alloys
Anti-Bacterial Agents
Bridged Bicyclo Compounds, Heterocyclic
Coated Materials, Biocompatible
Polymers
Ti-Zr alloy
poly(3,4-ethylene dioxythiophene)
Niobium
Durapatite