[Investigation on the health status of workers exposed to dimethylformamid]

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Dec 20;36(12):896-899. doi: 10.3760/cma.j.issn.1001-9391.2018.12.003.
[Article in Chinese]

Abstract

Objective: By analyzing the examination results of physical examination of workers exposed to DMF among 32 factories in some areas of a province, to investigate the working years of dimethylformamide (DMF) poisoning and the impact on the health status of exposed workers, and to explore the targeted intervention strategies. Methods: From February to May 2018, 2, 457 workers exposed to DMF in some areas of Jiangsu Province were selected as survey targets. Cross-sectional survey was conducted to investigate the health status of workers exposed to health, And the health surveillance data, detection data of occupational disease risk factors in the workplace were collected and analyzed, respectively. Results: The positive rate of abnormal liver function and B-ultrasound of males exposed to DMF was significantly higher than that of females. The abnormal rates of liver function, blood pressure and B-ultrasound in workers aged between 60 and 69 were higher in contrast to those in any other age groups. And the differences was statistically significant. In particular, the highest rate of abnormal blood pressure was found in workers exposed 21-30 years (39.2%) , the highest rate of abnormal liver function was found in workers exposed 11-20 years (44.3%) , and the highest rate of abnormal B-ultrasound was found in workers exposed 0-10 years (60.4%) . Conclusion: Long-term exposure to dimethylformamide can affect workers' liver function and blood pressure. Specifically, with the increase of contact age, the degree of chronic damage to liver, cardiovascular and other organs also increases.

目的: 探讨接触甲基甲酰胺接触(DMF)企业工人的中毒易发工作年限及对接触工人健康状况的影响。 方法: 于2018年2至5月,选择江苏省内部分地区32家接触DMF企业的2 457工人作为调查对象,采用横断面开展对接触工人健康状况的调查,并对健康监护资料及工作场所职业病危害因素检测资料进行统计学分析。 结果: 接触DMF男性工人肝功能、B超异常阳性率高于女性,60~69岁年龄段接触工人的肝功能异常率、血压异常率和B超异常率高于其他年龄段,差异有统计学意义(P<0.05);21~30年工龄段接触工人血压异常率最高(39.2%,20/51),11~20年工龄段接触工人肝功能异常率最高(44.3%,120/271),0~10年工龄段接触工人B超异常率最高(60.4%,20/51)。 结论: 长期接触DMF会影响工人的肝功能和血压,且接触工龄的增加,对肝脏、心血管等器官的慢性损害程度也随之增加。.

Keywords: Dimethylformamide; Healthstatus; Investigation.

MeSH terms

  • Aged
  • Blood Pressure / physiology
  • Cardiovascular Diseases / chemically induced*
  • Chemical and Drug Induced Liver Injury*
  • China
  • Cross-Sectional Studies
  • Dimethylformamide / poisoning*
  • Female
  • Humans
  • Liver / drug effects
  • Liver / physiopathology
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Exposure / adverse effects*
  • Occupational Exposure / statistics & numerical data
  • Time Factors

Substances

  • Dimethylformamide