The role of dePARylation in DNA damage repair and cancer suppression

Muzaffer Ahmad Kassab; Xiaochun Yu

doi:10.1016/j.dnarep.2019.02.002

The role of dePARylation in DNA damage repair and cancer suppression

DNA Repair (Amst). 2019 Apr:76:20-29. doi: 10.1016/j.dnarep.2019.02.002. Epub 2019 Feb 8.

Authors

Muzaffer Ahmad Kassab¹, Xiaochun Yu²

Affiliations

¹ Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.
² Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address: xyu@coh.org.

Abstract

Poly(ADP-ribosyl)ation (PARylation) is a reversible post-translational modification regulating various biological pathways including DNA damage repair (DDR). Rapid turnover of PARylation is critically important for an optimal DNA damage response and maintaining genomic stability. Recent studies show that PARylation is tightly regulated by a group of enzymes that can erase the ADP-ribose (ADPR) groups from target proteins. The aim of this review is to present a comprehensive understanding of dePARylation enzymes, their substrates and roles in DDR. Special attention will be laid on the role of these proteins in the development of cancer and their feasibility in anticancer therapeutics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Damage*
DNA Repair*
Humans
Neoplasms / genetics*
Neoplasms / metabolism*
Neoplasms / pathology
Poly Adenosine Diphosphate Ribose / metabolism*
Protein Processing, Post-Translational*

Substances

Poly Adenosine Diphosphate Ribose

Abstract

Publication types

MeSH terms

Substances

Grants and funding