Clinical issue: Biliary diseases require fast and rational use of diagnostic tests by both gastroenterologists and radiologists.
Standard treatment: Standard diagnostic workup includes transabdominal ultrasound, endoscopic retrograde cholangiography (ERC), endoscopic ultrasound, direct cholangioscopy, magnetic resonance cholangiopancreatography (MRI/MRCP), and computed tomography (CT).
Treatment innovations: Modular cholangioscopy is a novel diagnostic method.
Diagnostic work-up: The goal of diagnostic examinations is the determination of the location of obstructions and differentiation of benign from malignant lesions.
Achievements: Transabdominal ultrasound is risk-free and can show the gallbladder in great detail providing high diagnostic accuracy in most conditions. Endoscopic ultrasound, ERC and/or cholangioscopy are powerful tools to investigate the large bile ducts but are associated with inherent procedural risks.
Practical recommendations: Gall bladder diseases can often be diagnosed with transabdominal ultrasound alone. Bile duct disease often requires the use of endoscopic ultrasound, ERC and/or cholangioscopy.
Keywords: Cholecystitis; Choledocholithiasis; Endosonography; Modular cholangioscopy; Transabdominal sonography.