Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis

Ocul Immunol Inflamm. 2020;28(2):209-216. doi: 10.1080/09273948.2019.1574838. Epub 2019 Feb 26.

Abstract

Purpose: The purpose of this study is to describe clinical features and visual outcomes of Japanese patients with posterior scleritis.Methods: Clinical records of 10 patients (13 eyes) presenting between 2006 and 2016 were retrospectively reviewed.Results: The mean age was 50.1 ± 20.8 years; 50% were women, and three patients had bilateral disease. Associated anterior scleritis (11 eyes, 85%) and serous retinal detachment (8 eyes, 62%) were common at presentation. Treatment consisted of corticosteroids (all patients) and immunosuppressive agents (seven patients). The mean subfoveal choroidal thickness was significantly reduced over follow-up [611 μm at baseline, 298 μm (p < 0.01) at 1 month, and 238 μm (p < 0.01) at 1 year]. Recurrent inflammation was observed in six patients. A best-corrected visual acuity of 0.8 or better was achieved in all 13 eyes at 3 years and 71% of eyes at 5 years.Conclusion: Although 60% of patients with posterior scleritis had recurrence, visual outcomes were favorable.

Keywords: Central choroidal thickness; corticosteroid; exudative retinal detachment; immunosuppression; posterior scleritis; visual outcomes.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Aged
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Scleritis / diagnosis*
  • Scleritis / drug therapy
  • Scleritis / epidemiology
  • Tomography, Optical Coherence / methods*
  • Visual Acuity*
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents