Analysis of long noncoding RNAs for acute rejection and graft outcome in kidney transplant biopsies

Biomark Med. 2019 Feb;13(3):185-195. doi: 10.2217/bmm-2018-0272. Epub 2019 Feb 26.

Abstract

Aim: To analyse long noncoding RNAs (lncRNA) in kidney transplant biopsies.

Methods: Using a data mining approach, we constructed expression profiles in kidney transplant cohorts (n = 1105) from Gene Expression Omnibus. Integrative analysis of the lncRNAs with acute rejection (AR), T-cell-mediated acute rejection (TCMR) and graft loss were performed.

Results: Six lncRNAs were identified as are associated with AR in the training and validating datasets, and with a risk score was generated with 3-lncRNAs that were predictive of graft loss (AUC = 0.73). MIR155HG is associated with AR, TCMR and graft loss. Plus it might be involved in several graft rejection and immune associated pathways.

Conclusion: Understanding the role of lncRNAs in AR and graft outcome in kidney transplant biopsies needs to be further investigated.

Keywords: MIR155HG; T-cell-mediated acute rejection; acute rejection; biomarker; data minding; graft loss; immune; kidney transplant; long noncoding RNA; signature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Allografts
  • Biomarkers / analysis*
  • Biopsy
  • Gene Expression Profiling*
  • Gene Expression Regulation
  • Glomerular Filtration Rate
  • Graft Rejection / diagnosis*
  • Graft Rejection / etiology
  • Graft Rejection / pathology
  • Humans
  • Kidney Transplantation / adverse effects*
  • Prognosis
  • RNA, Long Noncoding / genetics*

Substances

  • Biomarkers
  • RNA, Long Noncoding