Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa

Antimicrob Agents Chemother. 2019 Apr 25;63(5):e01927-18. doi: 10.1128/AAC.01927-18. Print 2019 May.

Abstract

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016. High prevalences of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed. The partially resistant genotype was homogeneously distributed in Africa with a modestly high prevalence (48%), whereas the super resistant genotype was only found in West Africa with a very low frequency (1.2%). The findings provided baseline data about the molecular markers of SP resistance.

Keywords: Africa; China; Plasmodium falciparum; SP resistance; genotype; malaria; mutation; pfdhfr; pfdhps.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa
  • China
  • Genotype
  • Humans
  • Malaria / parasitology
  • Mutation / genetics
  • Plasmodium falciparum / genetics
  • Plasmodium falciparum / metabolism*
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism*

Substances

  • Protozoan Proteins