The dark side of HDAC inhibition in ALS

EBioMedicine. 2019 Mar:41:38-39. doi: 10.1016/j.ebiom.2019.02.039. Epub 2019 Feb 23.
No abstract available

Keywords: Amyotrophic lateral sclerosis; Denervation; HDAC.

Publication types

  • Letter

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Animals
  • Disease Susceptibility
  • Histone Deacetylase Inhibitors / adverse effects*
  • Histone Deacetylase Inhibitors / therapeutic use
  • Histone Deacetylases / genetics
  • Histone Deacetylases / metabolism*
  • Humans
  • Mice
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Neuromuscular Junction / metabolism

Substances

  • Histone Deacetylase Inhibitors
  • Histone Deacetylases