Abstract
In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.
Keywords:
Human-induced pluripotent stem cell; YAP; hepatobiliary development; liver disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology
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Adult
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Animals
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Bile Ducts / cytology
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Bile Ducts / drug effects*
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Cell Differentiation
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Cell Line
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Chemical and Drug Induced Liver Injury / etiology
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Drug Development / methods*
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Drug Evaluation, Preclinical / methods
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Embryoid Bodies / drug effects
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Hedgehog Proteins / physiology
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Hepatocytes / drug effects
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Humans
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In Vitro Techniques
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Induced Pluripotent Stem Cells / cytology
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Induced Pluripotent Stem Cells / drug effects*
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Liver / cytology
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Liver / drug effects*
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Liver Diseases / pathology
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Liver Diseases / therapy*
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Models, Animal
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Signal Transduction / drug effects
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Transcription Factors / physiology
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Hedgehog Proteins
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Transcription Factors
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YAP-Signaling Proteins
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YAP1 protein, human