Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells

Exp Biol Med (Maywood). 2019 May;244(8):702-708. doi: 10.1177/1535370219834895. Epub 2019 Feb 26.

Abstract

In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.

Keywords: Human-induced pluripotent stem cell; YAP; hepatobiliary development; liver disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology
  • Adult
  • Animals
  • Bile Ducts / cytology
  • Bile Ducts / drug effects*
  • Cell Differentiation
  • Cell Line
  • Chemical and Drug Induced Liver Injury / etiology
  • Drug Development / methods*
  • Drug Evaluation, Preclinical / methods
  • Embryoid Bodies / drug effects
  • Hedgehog Proteins / physiology
  • Hepatocytes / drug effects
  • Humans
  • In Vitro Techniques
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / drug effects*
  • Liver / cytology
  • Liver / drug effects*
  • Liver Diseases / pathology
  • Liver Diseases / therapy*
  • Models, Animal
  • Signal Transduction / drug effects
  • Transcription Factors / physiology
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Hedgehog Proteins
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human