Discovery of HLA-B58:74, a novel HLA-B58 variant, in Singaporean Chinese individuals

HLA. 2019 Jun;93(6):496-497. doi: 10.1111/tan.13502. Epub 2019 Mar 19.

Authors

Louise Cho¹, Ashminder Kaur¹, Nezih Cereb², Py-Yu Lin³, Kuo-Liang Yang^{3

4}

Affiliations

¹ Donor Search Department, The Bone Marrow Donor Programme, Singapore.
² Histogenetics Inc., Histogenetics, HLA Laboratory, Ossining, New York.
³ Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, Hualien, Taiwan.
⁴ Department of Laboratory Medicine and Biotechnology, Buddhist Tzu Chi University, Hualien, Taiwan.

PMID: 30801947
DOI: 10.1111/tan.13502

Abstract

Nucleotide substitutions at residues 105 and 106 of HLA-B*58:01:01:01 result in a novel allele, HLA-B*58:74.

Keywords: HLA; HLA-B*58:74; Singaporean Chinese; sequence-based typing.

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH terms

Alleles
Asian People
Bone Marrow Cells / cytology
Codon
Exons
Genetic Variation*
HLA-B Antigens / genetics*
Haplotypes
Hematopoietic Stem Cells
Humans
Sequence Analysis, DNA
Singapore / ethnology
Tissue Donors

Substances

Codon
HLA-B Antigens
HLA-B58