Room-temperature phosphorescent γ-cyclodextrin-cucurbit[6]uril-cowheeled [4]rotaxanes for specific sensing of tryptophan

Chem Commun (Camb). 2019 Mar 7;55(21):3156-3159. doi: 10.1039/c9cc00097f.

Abstract

Room temperature phosphorescent (RTP) γ-CD-CB[6]-cowheeled [4]rotaxanes were synthesized by implanting a naphthalene axle into the cavity of iodine-substituted γ-CDs. The strong green RTP was quenched exclusively by Trp while no RTP quenching was observed with other major physiological amino acids or with the Trp-containing protein HSA, demonstrating a highly specific sensing of free Trp.

MeSH terms

  • Bridged-Ring Compounds / chemical synthesis
  • Bridged-Ring Compounds / chemistry*
  • Humans
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Luminescent Agents / chemical synthesis
  • Luminescent Agents / chemistry*
  • Luminescent Measurements / methods
  • Rotaxanes / chemical synthesis
  • Rotaxanes / chemistry*
  • Temperature
  • Tryptophan / analysis*
  • Tryptophan / blood
  • gamma-Cyclodextrins / chemical synthesis
  • gamma-Cyclodextrins / chemistry*

Substances

  • Bridged-Ring Compounds
  • Imidazoles
  • Luminescent Agents
  • Rotaxanes
  • gamma-Cyclodextrins
  • cucurbit(6)uril
  • Tryptophan
  • gamma-cyclodextrin