ACMSD: A Novel Target for Modulating NAD+ Homeostasis

Trends Endocrinol Metab. 2019 Apr;30(4):229-232. doi: 10.1016/j.tem.2019.02.002. Epub 2019 Feb 21.

Abstract

NAD+ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359-1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD+ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD+ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD+ deficiency.

Keywords: ACMSD; NAD(+); metabolism; niacin; tryptophan.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Carboxy-Lyases*
  • Homeostasis
  • Humans
  • Mice
  • NAD
  • Niacin*
  • Tryptophan

Substances

  • NAD
  • Niacin
  • Tryptophan
  • Carboxy-Lyases