Targeting DNA repair in precision medicine

Reena Beggs; Eddy S Yang

doi:10.1016/bs.apcsb.2018.10.005

Targeting DNA repair in precision medicine

Adv Protein Chem Struct Biol. 2019:115:135-155. doi: 10.1016/bs.apcsb.2018.10.005. Epub 2018 Dec 5.

Authors

Reena Beggs¹, Eddy S Yang²

Affiliations

¹ Department of Radiation Oncology, University of Alabama-Birmingham School of Medicine, Birmingham, AL, United States.
² Department of Radiation Oncology, University of Alabama-Birmingham School of Medicine, Birmingham, AL, United States; Hugh Kaul Precision Medicine Institute, University of Alabama-Birmingham School of Medicine, Birmingham, AL, United States. Electronic address: shyang@uabmc.edu.

PMID: 30798930
DOI: 10.1016/bs.apcsb.2018.10.005

Abstract

Precision medicine is an emerging treatment paradigm that aims to find the right therapy at the right time based on an individual's unique genetic background, environment, and lifestyle. One area of precision medicine that has had success is targeting DNA repair in cancer. DNA is exposed to constant stress and there are repair mechanisms in place to maintain genetic integrity. These repair mechanisms can be targeted as a treatment strategy. In this chapter, we will focus on current efforts to target DNA repair pathways as part of precision oncology-based treatments.

Keywords: DNA damage; DNA repair; Homologous recombination; PARP; Personalized medicine; Precision medicine; Targeted therapy.

Publication types

Review

MeSH terms

DNA Repair*
Humans
Precision Medicine*