Two symmetrical unsaturated acids isolated from Viscum album

Chin J Nat Med. 2019 Feb;17(2):145-148. doi: 10.1016/S1875-5364(19)30016-0.

Abstract

In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L-1, and the SC50 of 4.34 and 8.22 μmol·L-1, respectively.

Keywords: Antioxidant activity; Symmetrical unsaturated acid; Viscum album.

MeSH terms

  • Acetylene / chemistry
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Biphenyl Compounds / chemistry
  • Molecular Structure
  • Picrates / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Viscum album / chemistry*
  • Xanthine Oxidase / chemistry

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Plant Extracts
  • 1,1-diphenyl-2-picrylhydrazyl
  • Xanthine Oxidase
  • Acetylene