The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Yuanyan Dou; Binbin Lin; Hui Cheng; Changbao Wang; Mingming Zhao; Jie Zhang; Jing Wu

doi:10.1080/10641955.2019.1581215

The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Hypertens Pregnancy. 2019 May;38(2):65-72. doi: 10.1080/10641955.2019.1581215. Epub 2019 Feb 22.

Authors

Yuanyan Dou¹, Binbin Lin¹, Hui Cheng¹, Changbao Wang², Mingming Zhao¹, Jie Zhang¹, Jing Wu¹

Affiliations

¹ a School of Public Health , Medical College of Soochow University , Suzhou , China.
² b School of Clinical Medicine , Medical College of Soochow University , Suzhou , China.

PMID: 30794002
DOI: 10.1080/10641955.2019.1581215

Abstract

Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia.

Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model.

Results: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006).

Conclusion: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.

Keywords: Melatonin; meta-analysis; pathogenesis; preeclampsia; pregnancy.

Publication types

Meta-Analysis
Review

MeSH terms

Female
Humans
Melatonin / blood*
Pre-Eclampsia / blood*
Pre-Eclampsia / etiology
Pregnancy

Substances

Melatonin