Association between fetuin-A and prognosis of CAD: A systematic review and meta-analysis

Eur J Clin Invest. 2019 May;49(5):e13091. doi: 10.1111/eci.13091. Epub 2019 Mar 12.

Abstract

Background: Fetuin-A is an anti-inflammation and anti-calcification factor involved in the course of coronary artery disease (CAD). But the association between serum fetuin-A level and the prognosis of CAD patients was still controversial. To clarify the association between serum fetuin-A level and the prognosis of CAD patients, we conducted the present meta-analysis.

Methods: The included studies should be potentially relevant prospective studies published in English language before January 2019. The target population of the present meta-analysis was restricted to patients with CAD. The results of studies must report hazard ratio (HR) or Kaplan-Meier survival curve for all-cause mortality or incidence of secondary cardiovascular disease (CVD) events. The pooled HRs were analysed by the method of meta-analysis.

Results: A total of four prospective studies, including 4256 participants with CAD disease, were chosen to be included. The pooled HR for all-cause mortality was 0.57 (95% CI: 0.37-0.87), showing a statistically significant association between high serum fetuin-A level and low all-cause mortality in CAD patients. For the incidence of secondary CVD events, the pooled HR was 0.86 (95% CI: 0.60-1.23), indicating no statistically significant association between serum fetuin-A level and incidence of secondary CVD events in CAD patients.

Conclusion: High serum fetuin-A level associated with lower all-cause mortality in patients with CAD. No association between serum fetuin-A level and incidence of secondary CVD events was found in patients with CAD.

Keywords: all-cause mortality; coronary artery disease; fetuin-A; meta-analysis; prognosis; secondary CVD incidence.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Aged
  • Biomarkers / metabolism
  • Cause of Death
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / mortality*
  • Female
  • Humans
  • Incidence
  • Male
  • Prognosis
  • Prospective Studies
  • alpha-2-HS-Glycoprotein / metabolism*

Substances

  • Biomarkers
  • alpha-2-HS-Glycoprotein