Abstract
Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / chemistry
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Carbamates / chemistry
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Chemistry Techniques, Synthetic
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Levetiracetam / chemical synthesis*
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Levetiracetam / chemistry
Substances
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Anticonvulsants
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Carbamates
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Levetiracetam