Adolescent Suicide as a Failure of Acute Stress-Response Systems

Annu Rev Clin Psychol. 2019 May 7:15:425-450. doi: 10.1146/annurev-clinpsy-050718-095625. Epub 2019 Feb 20.

Abstract

Suicide is the second leading cause of death worldwide for adolescents. Despite decades of research on correlates and risk factors for adolescent suicide, we know little about why suicidal ideation and behavior frequently emerge in adolescence and how to predict, and ultimately prevent, suicidal behavior among youths. In this review, we first discuss knowledge regarding correlates, risk factors, and theories of suicide. We then review why adolescence is a period of unique vulnerability, given changing biology and social network reorganization. Next, we present a conceptual model through which to interpret emerging findings in adolescent suicide research. We suggest that a promising area for future research is to examine adolescent suicide as a failure of biological responses to acute stress in the proximal moments of a suicidal crisis. After reviewing initial evidence for this conceptualization, we review future directions for studies on adolescent suicide.

Keywords: acute suicidal crisis; proximal risk factors; stress response; suicidal behavior; suicidal thoughts.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adolescent
  • Adolescent Behavior* / physiology
  • Humans
  • Models, Biological*
  • Stress, Psychological* / physiopathology
  • Suicide*