Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand

Katja Dankhoff; Aamir Ahmad; Birgit Weber; Bernhard Biersack; Rainer Schobert

doi:10.1016/j.jinorgbio.2019.02.005

Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand

J Inorg Biochem. 2019 May:194:1-6. doi: 10.1016/j.jinorgbio.2019.02.005. Epub 2019 Feb 13.

Authors

Katja Dankhoff¹, Aamir Ahmad², Birgit Weber¹, Bernhard Biersack³, Rainer Schobert⁴

Affiliations

¹ Inorganic Chemistry IV, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.
² USA Mitchell Cancer Institute, 1660 Springhill Avenue, Mobile, AL 36604-1405, USA.
³ Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany. Electronic address: bernhard.biersack@yahoo.com.
⁴ Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.

PMID: 30784705
DOI: 10.1016/j.jinorgbio.2019.02.005

Abstract

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.

Keywords: Anticancer drugs; DNA binding; Diindolylmethane; Reactive oxygen species; Vanadium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology*
Catechols / chemical synthesis
Catechols / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / pharmacology*
DNA / drug effects
Drug Screening Assays, Antitumor
G2 Phase Cell Cycle Checkpoints / drug effects
Humans
Indoles / chemical synthesis
Indoles / pharmacology*
Ligands
Male
Membrane Potential, Mitochondrial / drug effects
Mitochondria / drug effects
Reactive Oxygen Species / metabolism
Salmon
Vanadium / chemistry

Substances

Antineoplastic Agents
Catechols
Coordination Complexes
Indoles
Ligands
Reactive Oxygen Species
Vanadium
DNA
3,3'-diindolylmethane