DAMPening sterile inflammation of the kidney

Kidney Int. 2019 Mar;95(3):489-491. doi: 10.1016/j.kint.2018.12.007.

Abstract

Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al. demonstrate that soluble biglycan is a bimodal DAMP that both recruits proinflammatory macrophages and initiates resolution of inflammation and tissue remodeling in IRI, identifying a potential therapeutic target.

Keywords: ischemia reperfusion; macrophages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acute Kidney Injury*
  • Autophagy*
  • Biglycan
  • Humans
  • Hyaluronan Receptors
  • Inflammation
  • Kidney
  • Macrophages
  • Reperfusion Injury*
  • Toll-Like Receptor 4

Substances

  • Biglycan
  • CD44 protein, human
  • Hyaluronan Receptors
  • Toll-Like Receptor 4