Dynamics and management of oral anticoagulant treatment in chronic hepatitis C patients undergoing therapy with direct antiviral agents

J Chemother. 2019 Apr;31(2):86-89. doi: 10.1080/1120009X.2019.1571661. Epub 2019 Feb 20.

Abstract

Current regimens of direct-acting antiviral agents (DAA) are effective and safe for chronic hepatitis C (CHC). However, DAA often interfere with concomitant medications. We treated seven CHC patients with DAA who were on chronic anticoagulant treatment with warfarin, and describe the dynamics of prothrombin time, providing novel data, useful for the clinician.

Keywords: Drug–drug interaction; Hepatitis C; Warfarin.

MeSH terms

  • Administration, Oral
  • Aged
  • Aged, 80 and over
  • Anticoagulants / administration & dosage*
  • Antiviral Agents / therapeutic use*
  • Disease Management
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Hepacivirus / drug effects*
  • Hepatitis C, Chronic / drug therapy*
  • Hepatitis C, Chronic / virology
  • Humans
  • Male
  • Middle Aged
  • Prognosis

Substances

  • Anticoagulants
  • Antiviral Agents