Graphene nano-ribbon based high potential and efficiency for DNA, cancer therapy and drug delivery applications

Drug Metab Rev. 2019 Feb;51(1):91-104. doi: 10.1080/03602532.2019.1582661. Epub 2019 May 3.

Abstract

In this article, graphene oxide Nano ribbons (GONRs) and its high potential for using in medical fields have been reviewed. Recently, Graphene Nano ribbons (GNRs) has been a field of interest in biological methods and disease treatment such as drug delivery, DNA applications, and photothermal cancer therapies. GNRs demonstrate more efficient properties rather than other graphene-based Nanomaterials due to their larger surface area. These novel properties made them into a remarkable substitute material for biological fields as they have different cytotoxic effects and almost nontoxic to human health and the environment. In this study, some of the significant effects of GNRs such as Geno toxicity effects in human mesenchymal stem cells, DNA assembly, drug delivery agents, and the use of PEGylated GNRs in photothermal cancer therapy has been investigated.

Keywords: Nano ribbon; PEGylated; anti-cancer; drug delivery; gene therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA / chemistry*
  • Drug Delivery Systems / methods
  • Graphite / chemistry*
  • Humans
  • Nanoparticles / chemistry*
  • Nanostructures / chemistry

Substances

  • graphene oxide
  • Graphite
  • DNA