OPN gene locus is associated with the risk of knee osteoarthritis: a case-control study

Biosci Rep. 2019 Feb 27;39(2):BSR20182023. doi: 10.1042/BSR20182023. Print 2019 Feb 28.

Abstract

Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) < 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.

Keywords: OPN; knee osteoarthritis; single nucleotide polymorphism.

MeSH terms

  • Aged
  • Asian People / genetics
  • Case-Control Studies
  • China / epidemiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / epidemiology
  • Osteoarthritis, Knee / genetics*
  • Osteopontin / genetics*
  • Polymorphism, Restriction Fragment Length*
  • Protective Factors

Substances

  • Osteopontin