Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation

Chen Chu; Haiya Zhang; Shijie Cui; Bin Han; Lixiao Zhou; Ning Zhang; Xuan Su; Yujie Niu; Wen Chen; Rui Chen; Rong Zhang; Yuxin Zheng

doi:10.1016/j.jhazmat.2019.02.026

Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation

J Hazard Mater. 2019 May 5:369:180-190. doi: 10.1016/j.jhazmat.2019.02.026. Epub 2019 Feb 10.

Authors

Chen Chu¹, Haiya Zhang², Shijie Cui³, Bin Han¹, Lixiao Zhou¹, Ning Zhang¹, Xuan Su¹, Yujie Niu⁴, Wen Chen⁵, Rui Chen⁶, Rong Zhang⁷, Yuxin Zheng⁸

Affiliations

¹ Department of Toxicology, Hebei Medical University, Shijiazhuang, 050017, PR China.
² Deportment Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang, 050017, PR China.
³ Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, PR China.
⁴ Deportment Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, PR China.
⁵ Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, PR China.
⁶ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Dingjiaqiao 87, Nanjing, 210009, PR China.
⁷ Department of Toxicology, Hebei Medical University, Shijiazhuang, 050017, PR China; Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, PR China. Electronic address: rongzhang@hebmu.edu.cn.
⁸ Department of Toxicology, Public Health College, Qingdao University, 266000, Qingdao, PR China. Electronic address: yxzheng@qdu.edu.cn.

PMID: 30776601
DOI: 10.1016/j.jhazmat.2019.02.026

Abstract

PM2.5 pollution has been associated with numerous adverse effects including cardiovascular, respiratory and metabolic diseases as well as emotional disorders. However, the potential mechanism has not known clearly. Twenty-four rats were divided into 3 groups and exposed to various airs: filtered air (FA), unfiltered air (UA) and concentrated PM2.5 air (CA), respectively. Thirty wild type (WT) and 30 Nrf2 knockout (KO) mice were divided into 2 groups and exposed to FA and UA, respectively. The changes of neurobehavioral function, neurotransmitter secretion, toxic elements deposition, oxidative stress and the inflammation in prefrontal cortex were investigated during 9-12 weeks with/without PM2.5 exposure. Results showed that CA rats and KO-UA mice emerged obviously depressive-like responses. Li, Be, Al, Cr, Co, Ni, Se, Cd, Ba, Ti and Pb could deposit in the prefrontal cortex of rats after PM2.5 exposure. The neurotransmitters were significantly disorder in prefrontal cortex of CA rats. The NLRP3 signaling pathway was more activated in Nrf2^-/- than WT mice after PM2.5 exposure for 9 weeks. Nrf2/ NLRP3 signaling pathway modulating the inflammation might play an important role in the depression induced by ambient PM2.5.

Keywords: Depression; Inflammation; NLRP3; Nrf2; PM2.5.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants / adverse effects
Animals
Behavior, Animal
Brain / drug effects*
Brain / metabolism
Depression / chemically induced*
Inflammasomes
Inflammation
Male
Mice
Mice, Knockout
NF-E2-Related Factor 2 / genetics
NF-E2-Related Factor 2 / metabolism*
NLR Family, Pyrin Domain-Containing 3 Protein / genetics
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
Neurotransmitter Agents / metabolism
Oxidative Stress
Particle Size
Particulate Matter / adverse effects*
Rats
Rats, Sprague-Dawley
Signal Transduction

Substances

Air Pollutants
Inflammasomes
NF-E2-Related Factor 2
NLR Family, Pyrin Domain-Containing 3 Protein
Neurotransmitter Agents
Nfe2l2 protein, mouse
Nfe2l2 protein, rat
Nlrp3 protein, mouse
Nlrp3 protein, rat
Particulate Matter