A Case of Renal Involvement in B Lymphoblastic Lymphoma Leukemia

Clin Lab. 2019 Jan 1;65(1). doi: 10.7754/Clin.Lab.2018.180726.

Abstract

Background: Renal involvement is rare in B lymphoblastic lymphoma (B-LBL). The authors describe a rare case of renal involvement in a 21-year-old male patient with B lymphoblastic lymphoma leukemia, presenting with severe lactic acidosis.

Methods: Hematologic investigation, bone marrow aspirate and biopsy, cytogenetic analysis and renal biopsy were performed.

Results: The patient achieved complete hematological remission (CHR) after induction therapy with the regimen of VDCP and received consolidation chemotherapy regularly. He remained CHR until now.

Conclusions: Renal biopsy, bone marrow aspirate, and biopsy are important to confirm a correct diagnosis. Renal involvement in B-LBL as a prognostic factor needs further studies.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / classification
  • Acidosis, Lactic / drug therapy
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Humans
  • Kidney / drug effects
  • Kidney / pathology*
  • Male
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Remission Induction
  • Young Adult