Ontogeny of ADME Processes during Postnatal Development in Man and Preclinical Species: A Comprehensive Review

Drug Metab Dispos. 2019 Mar;47(3):295. doi: 10.1124/dmd.118.084350.

Authors

Luc M De Schaepdrijver¹, Pieter P J Annaert², Connie L Chen²

Affiliations

¹ Janssen R&D, Beerse, Belgium (L.M.D.S.); University of Leuven, Leuven, Belgium (P.P.J.A.); and Health and Environmental Science Institute, Washington, DC (C.L.C.) ldschaep@its.jnj.com.
² Janssen R&D, Beerse, Belgium (L.M.D.S.); University of Leuven, Leuven, Belgium (P.P.J.A.); and Health and Environmental Science Institute, Washington, DC (C.L.C.).

PMID: 30770345
DOI: 10.1124/dmd.118.084350

No abstract available

Publication types

Review

MeSH terms

Absorption, Physiological / physiology
Age Factors
Animals
Child
Child Development / physiology*
Child, Preschool
Drug Evaluation, Preclinical / methods*
Gastrointestinal Tract / growth & development
Humans
Infant
Infant, Newborn
Kidney / growth & development
Liver / growth & development
Metabolic Clearance Rate / physiology*
Models, Animal
Models, Biological
Pharmaceutical Research / methods*