Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?

Jakob Frimodt-Møller; Anders Løbner-Olesen

doi:10.1016/j.tim.2019.01.005

Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?

Trends Microbiol. 2019 Apr;27(4):291-293. doi: 10.1016/j.tim.2019.01.005. Epub 2019 Feb 12.

Authors

Jakob Frimodt-Møller¹, Anders Løbner-Olesen²

Affiliations

¹ Department of Biology, Functional Genomics, University of Copenhagen, Copenhagen, Denmark; Center for Peptide-Based Antibiotics, University of Copenhagen, Copenhagen, Denmark. Electronic address: jakob.frimodtmoller@bio.ku.dk.
² Department of Biology, Functional Genomics, University of Copenhagen, Copenhagen, Denmark; Center for Peptide-Based Antibiotics, University of Copenhagen, Copenhagen, Denmark. Electronic address: lober@bio.ku.dk.

PMID: 30770171
DOI: 10.1016/j.tim.2019.01.005

Abstract

A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to high-level resistance, this highlights how transiently tolerant cells can develop resistance in response to antibiotic treatment.

MeSH terms

Anti-Bacterial Agents / pharmacology
Bacterial Outer Membrane Proteins / metabolism
Carrier Proteins / genetics
Carrier Proteins / metabolism
Drug Resistance, Bacterial / drug effects
Drug Resistance, Bacterial / genetics*
Drug Resistance, Bacterial / physiology
Drug Tolerance / genetics*
Drug Tolerance / physiology
Escherichia coli / drug effects
Escherichia coli / physiology
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial
Membrane Transport Proteins / metabolism
Mutation
Up-Regulation*

Substances

AcrAB-TolC protein, E coli
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Carrier Proteins
Escherichia coli Proteins
Membrane Transport Proteins