Insulin-like growth factor-binding protein 7 (IGFBP 7) as a new biomarker in coronary heart disease

Adv Med Sci. 2019 Mar;64(1):195-201. doi: 10.1016/j.advms.2018.08.017. Epub 2019 Feb 13.

Abstract

Purpose: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI).

Materials/methods: The study group consisted of 212 patients with MI and 75 patients with stable CAD, the control group included 100 healthy volunteers. IGFBP-7 serum concentration was measured.

Results: IGFBP-7 value was considerably higher in the study group (MI and CAD patients - 35.1 ng/ml (P = 0.000001) and 32.7ng/ml (P = 0.0001), respectively), than in the controls - 25.2ng/ml. No statistically significant differences between IGFBP-7 concentrations in the MI and CAD group were found. No relationship between IGFBP-7 and the coronary lesions advancement in the study group was observed. No changes in IGFBP-7 concentration in the MI patients during hospitalization were observed. In the group of MI patients who died during follow-up, a considerably higher cIMT values were found whereas no statistically significant difference was observed in relation to IGFBP-7 (34.6 vs. 35.2 ng/ml).

Conclusions: IGFBP-7 is a good biomarker of CAD occurrence but not of its advancement. We demonstrated the existence of the relation between higher IGFBP-7 concentration and the selected classical risk factors of cardiovascular events as well as cIMT values. IGFBP-7 cannot serve as a marker of acute ischemia. Also, IGFBP-7 was not confirmed as a predictor of mortality in the MI patients.

Keywords: Carotid intima-media thickness; Coronary artery disease; Insulin-like growth factor-binding protein-7 (IGFBP-7); Myocardial infarction.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers / blood
  • Carotid Intima-Media Thickness
  • Case-Control Studies
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diagnostic imaging
  • Female
  • Follow-Up Studies
  • Humans
  • Insulin-Like Growth Factor Binding Proteins / blood*
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • ROC Curve
  • Young Adult

Substances

  • Biomarkers
  • Insulin-Like Growth Factor Binding Proteins
  • insulin-like growth factor binding protein-related protein 1