Mesoporous, degradable hyaluronic acid microparticles for sustainable drug delivery application

Nurettin Sahiner; Selin S Suner; Ramesh S Ayyala

doi:10.1016/j.colsurfb.2019.02.015

Mesoporous, degradable hyaluronic acid microparticles for sustainable drug delivery application

Colloids Surf B Biointerfaces. 2019 May 1:177:284-293. doi: 10.1016/j.colsurfb.2019.02.015. Epub 2019 Feb 8.

Authors

Nurettin Sahiner¹, Selin S Suner², Ramesh S Ayyala³

Affiliations

¹ Chemistry Department, Faculty of Science & Arts, and Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100, Canakkale, Turkey; Department of Ophthalmology, School of Medicine, University of South Florida Eye Institute, 12901 Bruce B. Downs Blvd., MDC 21 Tampa, FL, 33612, United States. Electronic address: sahiner71@gmail.com.
² Chemistry Department, Faculty of Science & Arts, and Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100, Canakkale, Turkey.
³ Department of Ophthalmology, School of Medicine, University of South Florida Eye Institute, 12901 Bruce B. Downs Blvd., MDC 21 Tampa, FL, 33612, United States. Electronic address: rayyala@health.usf.edu.

PMID: 30769230
DOI: 10.1016/j.colsurfb.2019.02.015

Abstract

Porous and degradable hyaluronic acid (HA) microparticles was synthesized in a single step using different ratio of crosslinker, divinylsulfone (DVS) ranging between 2.5 and 100% mole ratio of HA repeating unit. HA particles less than 25% (≤10%) crosslinker ratio were found to be mesoporous and provided the highest surface area, calculated as 21.54±10.31 m²/g for 2.5% crosslinked HA particles via BET analysis. Hydrolytic degradation of 2.5% crosslinked HA microparticles in PBS (pH 7.4) and at 37.5 ºC revealed a linear weight loss up to 20 days and 94.5±4.5% weight loss for 30 days was attained. A wide spectrum antibiotic, Vancomycin as a model drug was loaded to mesoporous HA particles via directly loading from aqueous corresponding solution and by chemical conjugation method to obtain controllable and sustained release profiles from HA particles. Up to 168 h linear vancomycin release (50.5±4.2 mg/g) was accomplished from 2.5% DVS crosslinked HA particles.

Keywords: Degradable HA particle; Drug conjugation; Hyaluronic acid particle; Microgel/nanogel; Porous particle.

MeSH terms

Drug Delivery Systems*
Drug Liberation
Hyaluronic Acid / chemical synthesis
Hyaluronic Acid / chemistry*
Particle Size
Porosity
Surface Properties
Vancomycin / chemistry*

Substances

Vancomycin
Hyaluronic Acid